Pregnant women with SARS-CoV-2 infection have a higher risk of death and severe pneumonia: an appropriate analysis of the incline score of a prospective national cohort study (VOC19Mx) – Martinez-Portilla – – Ultrasound in obstetrics and gynecology


Unmatched data have reported low rates of complications in pregnant women with COVID-19. This study compared COVID-19-related outcomes in pregnant women with non-pregnant women after adjusting for potential risk factors for severe outcomes.


The data were obtained from the National COVID-19 Data Registry of Mexico, which is a potential continuous cohort of people of any age with a clinically suspected SARS-CoV-2 infection and admitted to 475 monitoring hospitals. This study included pregnant and non-pregnant women of reproductive age (15-49 years) with COVID-19 confirmed by reverse transcription polymerase chain reaction. To adapt to the underlying risk factors, the incline score was adjusted for chronic obstructive pulmonary disease, asthma, smoking, hypertension, cardiovascular disease, obesity, diabetes, and age. The main result was death. Secondary outcomes were pneumonia, intubation, and admission to the intensive care unit (ICU).


The initial sample included 5,183 pregnant women and 175,908 non-pregnant COVID-19 patients. Gross (unmatched) rates of death, pneumonia, intubation and intensive care admission in pregnant and non-pregnant women were 1.5% vs. 1.5%, 9.9% vs. 6.5%, 8 , 1% compared to 9.9%, 13.0% compared to 6.9%, respectively. After adjusting the inclination score (5183 pregnant women and 5183 pregnant women), pregnant women had a higher chance of death (odds ratio) [OR] 1 · 65, 95% CI 1 · 30–2.09), pneumonia (OR 1 · 99, 95% CI 1 · 81–2 · 19) and admission to intensive care (OR 2.25, 95% CI 1 · 86-2 · 71) than women who are not pregnant, but similar chances of intubation (OR 0 · 93, 95% CI 0 · 70-1 · 25).


After adjusting for demographic and medical factors, pregnancy is a risk factor for death, intubation, and ICU admission in women of reproductive age-infected SARS-CoV-2.

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